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I am wondering if any one is aware of any structural (non-regulatory)
polymorphism in a P450 that affects its Vmax but not Km. I would think
any changes, e.g. in electron transport, heme incorporation, OR
interaction, etc, while may not directly affect binding of substrate
per se, will indirectly affect Km to some extent since Km is (k-1 +
k2)/k1 and k2 = kcat and Vmax = kcat after accounting for the total
number of enzymes.
Thanks in advance,
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