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Dear all,
I found that some authors used the term "free" to describe the
plasma concentration of the drug not conjugated into glucoronide/
sulphate/etc... form. Which could be the more apropriate term to
designate it, free or unconjugated? I think free give an idea about
unbound plasma concentration, in fact that was what I thought when I
first read the sentence.
Could anyone with more expertise clarify this, please
Thanks,
Victor
[Free often refers to unbound to protein while unconjugated usually
refers not metabolized as a conjugate - db]
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Dear Victor,
I agree with you," free" is related to the unbound fraction of the drug
--
Francoise BREE
XENOBLIS
francoise.bree.-a-.xenoblis.com
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The following message was posted to: PharmPK
Since the word "free" is ambiguous, it would be better not to use it
at all,
but to refer to "bound" and "unbound", "conjugated" and "unconjugated".
--
J K Aronson, University Department of Primary Health Care,
Rosemary Rue Building, Old Road Campus, Roosevelt Drive, Headington,
Oxford OX3 7LF
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