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G2 Research announces availability of pharmacokinetic modeling data sets
October 14, 2008
Lake Tahoe, CA- G2 Research , a company focused on the marketing and
use of data, models and tools to develop pharmacokinetic models, today
announced the commercial availability of its high quality in vivo and
in vitro assay data suitable for building PK models.
The ADME MODEL Data set is immediately available and contains assay
data for nearly 600 compounds, including more than 9,500 individual
* Caco-2 at 2 pH values with A/B B/A data
* Thermodynamic solubility at 5 pH values
* Blood plasma partitioning
* Protein binding (human and rat)
* Intestinal segment permeability measured in rabbit and rat
intestinal tissue A/B and B/A
* Multiple concentration human hepatocyte assay data
* CYP 2D6 and 3A4 inhibition
A related set of human in vivo data corresponding to the compounds
used in the in vitro assays is also available. These human data have
been analyzed by a single set of algorithms to provide target in vivo
profiles for the development of ADME models.
A comprehensive exclusive in vivo rat ADME data set not yet utilized
in any commercial model is also available.
Based on original research conducted by NaviCyte, Inc. and acquired by
Trega Biosciences in 1998 and subsequently by LION bioscience in 2001,
the data sets consist of individual in vitro and in vivo assay data
points of hundreds of hand selected pharmaceutical compounds. These
data sets were used in the development of the iDEA(TM) and PK
Express(TM) pharmacokinetic simulation models which were marketed by
The compounds represented in the data sets were chosen to produce
robust, diverse data pools of in vitro and human pharmacokinetic
clinical data, consisting of both drug development successes and
failures, to train ADME models.
"What makes the data sets unique" says Founder and President Dr.
George Grass, "is that all the data has been obtained using rigorous
Standard Operating Procedures, collected in one lab, often by a single
technician and so is far more consistent than anything that has been
previously in the public domain. In the past, customers of the models,
which were developed from these data sets, were demanding access to
the underlying data but could not obtain access. Many wanted to use
the data in their own proprietary models. Now we are making the data
commercially available for the first time".
The data is provided in Oracle, Excel or flat text file format.
Compound name, structure, assay data as well as complete assay
protocols are provided.
In addition to the currently available datasets, G2 Research will make
available many of the development tools and the models which were part
of the iDEA(TM) and PK Express(TM) simulation products and will
license technology covered under its patents.
For more information about the data sets or the assays protocols
contact G2 Research at info.aaa.admemodel.com and visit
About G2 Research, Inc.
G2 Research Inc, founded in 2001, provides consulting services to
pharmaceutical organizations, primarily in the area of drug delivery
and predictive pharmacokinetics. Since acquiring the assets of the
iDEA(TM) and PK Express(TM) products from Lion bioscience, G2R is
using these tools in its consulting business and making those assets
available to the market. The initial offering is the high quality in-
vitro and in-vivo ADME and pharmacology data sets specifically
constructed for the purpose of building predictive models. G2
licenses the data to pharmaceutical companies for internal research
use under a variety of flexible commercial agreements.
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