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Thermo Fisher Scientific pleased to announce the release of Kinetica
This can be downloaded from www.kineticadownload.com for a trial
version. The accompanying manuals are also available at the site.
Numerous new features were included in this version:
(1) A new non-compartmental analysis method for sparse sampling design
takes into account repeat animal use to compute the standard error of
the AUC. Repeat sampling is taken into consideration in this
algorithm. Standard deviation of Cmax and the degrees of freedom are
also output from this method. Method is based on the Bailer-
Satterwaithe (also known as the Jia-Needleman-Bailer) method. Other
features in this method include the ability to impute a 0
concentration value at time 0, if one is not available.
(2) Non-compartmental analysis for steady state profiles has extended
capability to perform regression of the terminal phase concentration-
time points. The method has a more extensive data handling for
starting concentrations, including user-defined time-point such that
the system will use the corresponding concentration as the initial
(3) Superposition method for variable dosing intervals is a model-
independent method to estimate steady-state profiles based on single-
(4) Greater control and options for handling flagged data in the
analyses and statistics for creating tables. Because Kinetica allows
users to flag the data for BLQ, users do not need to artificially
manipulate BLQ data. BLQ handling in the analysis methods provides
options for user to map a separate LLOQ column and use LLOQ, LLOQ/2,
LLOQ/3 and LLOQ/4 in the pharmacokinetic computations, in addition to
setting flagged BLQ data to 0 or missing.
(5) Users can introduce textual information associated to the time-
concentration profiles. Textual comments can be incorporated to the
worksheet level in Kinetica, the comments from Watson LIMS for a
particular concentration can also be imported into the worksheet level.
(6) Additional table structures for sparse sampling design.
(7) More graphical methodologies. Interface to SigmaPlot for more
(8) Users can map Watson LIMS database columns to a specific custom
Kinetica template during the import process.
A new set of in vitro - in vivo correlation (IVIVC) templates that run
on version 5.0 will be available in January 2009. Our IVIVC templates
will be part of the base product and no additional licenses will be
required to use them. I will make an announcement when they become
available for download from our website.
For current Kinetica users, please request for an updated license from sales.informatics.at.thermofisher.com
, as we have incorporated a new licensing mechanism in this new version.
For more details of all the new additions to Kinetica 5.0, please
refer to the release notes provided in our website.
Sherwin K Sy
Thermo Fisher Scientific
1601 Cherry Street, Suite 1200
Philadelphia, PA 19103
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