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I am working on a drug that is locally acting in GI. It is water
insoluble. I want to model the in vitro dissolution behaviour to
predict efficacy. Being a water insoluble molecule, is the dissolution
or wetting of the drug slower process or both needs to be considered?
In case of formulation changes, such as surfactant addition, I would
like to see the effect in the efficacy. I appreciate if anybody can
provide ideas on how to model this?
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