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Dear All,
I will appreciate if any one can explain with reference
1. When to select blood, plasma or serum for calculation of PK
parameters in case of NCE's.
2. When to calculate blood to plasma ratio of NCE's
3. What is the regulatory requirements for IND submission
Is it okay to calculate serum concentration for the NCE's in which
their protein binding is less?
Regards
Subramanian
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