Back to the Top
First of all I would like to thank all the responders to my last
I would like to ask another question regarding the same two-
compartment model. Suppose that the inter-compartment exchange follows
some saturation pattern. i.e. the rate is slow when the concentration
gradient is low, gets higher as the concentration gradient increases
and reaches it's maximum value as the gradient gets further bigger.
How legitimate is it to model it using Michaelis-Menten equation as
dC/dt=-(C1-C2)Vmax/(Km + (C1-C2))
where Vmax is the maximum exchange rate constant and Km is the MM
(more convinient representation is here: http://mathbin.net/743)
[Interesting use of LaTeX for equation presentation - db]
Back to the Top
The following message was posted to: PharmPK
To get the most from David's link you may need to add a LaTex viewer to
For Firefox (I'm still at 2.0 for the moment) I'm using the one from
As the URL suggests, you need greasemonkey installed beforehand.
It translates LaTex to MathML.
All the very best,
Bernard Murray, Ph.D.
Drug Metabolism, Gilead Sciences, Foster City CA
[I think the real problem was the ')' at the end of the url... I
usually try to put any urls on their own line but missed this one. Try
It worked within the original message but not after it went out
through PharmPK. However, the reference to greasemonkey is still
interesting and may be of some use to fellow PharmPKers. I'm currently
revising a course webpage and I'm sure equations will be involved (in
my case using LaTeXiT and TeX FoG etc.) - db]
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Michaelis-Menten inter-compartment exchange" as the subject
Support PharmPK by using the
Copyright 1995-2011 David W. A. Bourne (email@example.com)