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Can someone please tell me whether we can infuse 100% PEG400 in monkeys.
If yes then how long should you take to infuse 2mL of PEG400 solution
Can the monkeys tolerate it?
Amit Shah, Ph.D.
Sr. Research Scientist
Frontage Laboratories, Inc.
75 E Uwchlan Ave, Suite 126
Exton, PA 19341
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Summary: Several antiepileptic drugs, such as carbamazepine and
clonazepam, have low bioavailability in solid form and are insoluble
in an aqueous solution. Alcohol solvents are often employed as
vehicles when these drugs are studied in animal models. Secondary and
particularly tertiary alcohols are suspected of some anticonvulsant
activity. The present research evaluated the possibility that
polyethylene glycol 400 (PEG 400) might be efficacious, toxic, or
both. Monkeys (N = 11) rendered epileptic by aluminum-hydroxide were
administered PEG 400 by constant rate (1 ml/hr) intravenous infusion
for 3-4 weeks, preceded and followed by several weeks of baseline. At
a concentration of 60%, PEG 400 significantly reduced seizure
frequency, but also exhibited severe side effects. These findings
suggest that experimental testing of anticonvulsants may be
compromised when this or similar solvents are used chronically for
[this link didn't work for me - maybe it requires a log-in - db]
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