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Thanks in advance for assistance with this question.
Where can I find information regarding which protein a drug is bound to
in order to determine if it displaces another?
I understand there are multiple proteins and multiple sites on a
protein. Just because they are both protein bound does not mean one
will diplace the other - unless they complete directly for the same
binding site. Or one creates a conformational change, resulting in
decreased binding for the other.
The two medications I am interested in are bupropion (84% bound) and
bupivacaine (95% bound). They can both cause seizures. I am interested
to know if they compete for the same sites or it either would displace
the other. The patient had other risk factors as well.
Adrienne Lacheta RPh, CSPI (Certified Specialist in Poison Information)
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