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I obtained this information from a drug manufacturing company: "
result of terminal half-lives of 0.2 (0.1) min (alpha-phase) and 8.2
(6.3) min (beta-phase)."
would this mean that the drug works in a 2-compartment model? also
from another site i found that 2-compartment models refer to drugs
that take long to equilibrate with peripheral tissues where as it
seems to me that this particular drug has very short half lives.
btw the drug is alprostadil
any help will be very welcome!
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The following message was posted to: PharmPK
The reported two half-lives mean that the researches that published that
data used two-compartment model to analyze the experimental data.
Theoretically, this doesn't mean that two compartment model is the best
way to describe the behavior of this drug in the body, but if you don't
have the access to the raw PK data, you only have to trust that they
know what they are doing.
Regarding the issue of fast half-lives and slow inter-compartment
equilibrium. The general assumption is that in order to observe
multi-compartmental kinetics, the time to equilibrium has to be slow
enough with respect to the measurement resolution. It is obvious that if
alpha half life is 0.1 min (6 sec), and the measurements are done every
minute, the multicomparmtment behavior will not be presented.
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