Back to the Top
Dear Members
I would like to get some insight how to normalize Cmax and AUCs with
body weight in human. I have noticed that some articles estimated
body weight normalized Cmax and AUCs by dividing individual body
weight. However, some people assert that body weight normalization
can be conducted multiplying Cmax or AUCs by individual body weight.
It is confusing to me. Any feedback will be welcomed.
Sincerely
Back to the Top
The following message was posted to: PharmPK
Hi Sun Ku,
If you are normalizing by mg/kg Doses then you get
Cmax ng divided by Dose mg
-- ---
mL kg body weight
This is equal to
Cmax ng x kg body weight
-- --
mL mg dose
Susan Shoaf
Otsuka Pharmaceutical Development
& Commercializtion, Inc.
Rockville Md 20850
Back to the Top
Hi,
A normalization of Cmax and AUC by dividing these quantities by the
subject body weight is very easy to perform. In fact, however it
exhibits the same scientific meaning as for example a normalization of
the subject appetite by her/his body weight.
With best regards,
Maria Durisova DSc (Math/Phys)
http://www.uef.sav.sk/durisova.htm
http://www.uef.sav.sk/advanced.htm
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Weight adjusted Cmax and AUCs" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)