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We have recently come across some research papers,
wherein use of N-Methyl-D-glucamine in the oral formulation of a
compound (which has solubility issues) for rat PK is indicated. I am
aware that NMG acts as a substrate of OCT and is used as a Na+
substitute in systems to maintain physiological solutions as isotonic
but I am not sure whether it would help increasing the solubility.
I would highly appreciate if the members of this forum could throw
some light on why it is being employed in pre-formulation?
Thanks in advance
Advinus Therapeutics Pvt. Ltd.,
International Biotech Park,
Genesis Square, Bio Resource Centre,
2nd Floor, Phase II, Hinjewadi,
Pune- 411 057
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