Back to the Top
Dear Wang,
I am a beginner in the pharmacokinetic field. I have read you discussions on pharmacokinecs involving clearance, volume of distribution and t1/2. I wanted to know how can be clearance or volume of distribution determined by the formula V or CL=A*(bodyweight)**B(exponent)
From where the exponent (B) came and what is the rationale behind it.
I am sure you'll help me for development of drugs using pharmacokinetics and make me understand the concept behind it. I'll be waiting for you positive response.
Kind Regards
Tarique, M. Pharm
Jamia Hamdard, New Delhi
India
Back to the Top
The following message was posted to: PharmPK
Have a look at this link for a discussion of the 3/4 power law for
allometric scaling of things related to metabolic rate:
http://en.wikipedia.org/wiki/Kleiber%27s_law
Back to the Top
Dear Tariq,
I beleive that you should have to go through with books witten by shargil and gibaldi. This will help you in all day to day PK releated problems.
With Regards,
Dr. Tushar Nahata
[See http://www.boomer.org/pkin/book.html
- db]
Back to the Top
Hello Tarique,
exponent (B) is the allometric exponent which explains the rate of change of CL subjected to a change of body weight (mass).
To explain a bit further, when this exponential form is transformed to a linear function, this becomes
as follows: Log(CL) = Log A + B Log (BW) and A , B can be estimated from the intercept and slope of the linear regression. This slope (B) explains the rate of change of CL with a change of body weight.
Happy New year
Regards,
Martin
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Allometric exponents" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)