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I need a clarifcation on the following issues: 1. I am working with a
highly soluble compound. When i do the dissolution studies in various
media (HCl, water, buffers with pH 4.5 and 6.8) all the formulations
released the same amount of drug and the release profile is comparable
to innovator. So, how do i select the best formulation for my in vivo
studies. How do i statistically differentaite the formulations, can i
relay on any of the conventional parameters.
2. As i am working on orally disintegrating tablets, i would like to
know regarding the dosing of the dosage form in animals. Can i give it
in a suspension form by suspending the whole tablet in a few ml of
water just before adminstration to rabbits in particular or if i have
to dose it in the form of a tablet what is the convenient method to
adminster the tablet below the trachea. Providing the references and
comments on these issues is highly appreciable. Thank you Ravi
Sheshala School Of Pharmaceutical Sciences, Universiti Sains malaysia,
11800, Penang, Malaysia.
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