Back to the Top
The following message was posted to: PharmPK
We are working on a microspheres (MS) for oral delivery of
30 KD). After oral delivery of MS they will pass through the stomach
the intestine MS will be uptaken by Peyer's Patches (PP). Once the PP
the MS it will pass through the lymphatic system to deliver the drug
into the systemic circulation. We would like to know the amount of drug
release before the MS uptake by PP and after.
According to my understanding, I think the amount of drug that is
before MS uptake by PP cannot be counted since it is a macromolecule
not permeate, even if it permeates it will be metabolized in the
after PP uptake the drug that is released from the MS is the amount
available in the systemic circulation.
We are trying to develop a biorelevant dissolution method for these
want to deliver these MS for rats in fasted state. Since these MS are
acid labile we want to disperse MS in saline and deliver it in a
(I used the terms drug/macromolecule interchangeably)
I appreciate your feedback and support for our project work.
I would like to thank you all for your time.
Back to the Top
As your MS is acid labile so probably it will release the
macromolecules in the stomach...so i doubt that it will permeate
through the PP.
As for as dissolution method is concerned you may use SGF and SIF for
Dr. Tushar Nahata
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Dissolution method development for microspheres" as the subject
Support PharmPK by using the
Copyright 1995-2011 David W. A. Bourne (email@example.com)