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I have recently completed development of PKQuest_Java, a freely
distributed interactive physiologically based software (PBPK) routine.
It can be downloaded from
I hope that some of you on this list will try it out. I would greatly
appreciate having feedback on the interactive design, the operation,
I am sure that it has a number of bugs and your help on this would
also be valuable.
The only requirement for running it is that you have a recent version
of the Java Runtime Environment (JRE) software installed.
A brief list of some of the features of the software:
Intuitive and versatile interactive interface.
Pre-programmed optimized human parameter data set (but, arbitrary
values can be used).
Allows time dependent changes in the PBPK parameters.
Non-linear parameter optimization.
Unique approach to determine the oral "first pass metabolism" of
Volatile solutes and pulmonary perfusion/ventilation heterogeneity.
Input and output of Excel spreadsheet data.
Antecubital vein sampling option.
Included in the download is a detailed "Tutorial" that describes the
main features of PKQuest_Java through detailed worked example using
the following solutes:
D2O, amoxicillin, ethanol, thiopental, propofol and desflurane
I would hope that this program and tutorial could form the basis of a
web based interactive course that focuses on the relationship between
the physical chemical properties of a solute and its
pharmacokinetics. Again, I would be interested in feedback about
suggestions or modifications that would improve its usefulness for
Thanks in advance,
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