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I am a graduate student working with inflammatory animal model. However, I could not get the opportunity to run my data with PKPD software. Is there some graduates or some other people who happen to have the opportunity to work with PKPD software and want to find some real data to do the modeling and simulation? I want to share my data and get a chance to see how does the modeling and simulation come out.
My experiment is designed as below:
Experiment model: lps induced inflammatory rat model
Measurement: Biomarker in circulating system
Pre_treatment (at different time points) with single dose of a small molecular lead compound
Mechanism of inhibition: through inhibition of NF-kb transduction pathway
Possible response model: indirect response model
Although we have make a conclusion that under current dose of LPS and the lead compound, the inhibititory activity could last as long as 12h (compared to no treatment group, showing around 50% inhibition), but we still could not know the kinetic of the inflamamation and inhibition.
I do not have PK data and I found big individual variability which may be a problem. It is designed as parallel design (no individual Time course of Response); and we will soon have the consequential cross-over data to show the individual inhibition rate.
If anyone would like to do me a favor, please contact me by fengzeng0827.at.gmail.com, thanks all very much.
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