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we had after a lesson the discussion if the potential of having an
increase of AUC by interaction is limited by the max. 100%
bioavailability of a drug or not.
If less than 5% of the systemic exposure determined by AUC of total
radioactivity is caused by the drug and 95% are metabolite AUC, but
absolute bioavailability is 33.3%, is my worst case scenario for DDI a
2-fold increase or may I have up to 19-fold more drug after
coadministration of an potent inhibitor?
Are there known examples where the increase is much higher than as it
was with 100% bioavailability?
And where could I find data on % of total radioactivity AUC for drugs?
Thanks for your ideas,
Friedrich Unseld (still student)
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