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Is there any way to use WinNonlin NCA to calculate IV bolus+IV
infusion PK please?
Thanks for your input!
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The following message was posted to: PharmPK
The equations for NCA are by definition for single-dose($) event
profiles; as an *approximation* you could tell the software the total
amount of dose delivered in your two doses and give the duration of the
infusion but estimates of Clearance etc may not be entirely valid. It
will however give you observed Cmax, AUC etc; which may be all your
require for your assessment.
Or if want to get into compartmental modelling, you can use the
built-in PK models 15, 16 or 17. Or alternatively another workaround is
to use a built-in infusion model with the workaround of giving two
doses; just set the duration of infusion for your bolus (the first dose)
to a short duration e.g. 0.00555h would indicate you gave the bolus over
Or you can write a user model. You may also like to consider
looking at the graphical model builder that is included in Phoenix
WinNonlin 6.0 that is now available, the NLME (population) module will
be released in a few weeks, see the webinar on Thursday, sign up here;
Or for a general introduction this recording is available too at
Introducing Phoenix(tm) WinNonlin(r) 6.0
Date: June 11, 2009
Time: 11:00am - 12:00pm EST
Speaker: Daniel Weiner, Ph.D., Sr. Vice President & CTO
This webinar provides an overview and demonstration of Phoenix WinNonlin
6.0, the next generation of the industry standard software tool for
PK/PD modelling and noncompartmental analysis. The demonstration covers
the major features of Phoenix WinNonlin 6.0, including: new workflow
functionality for easy visual creation and reuse of PK/PD analyses, data
visualization tools and high quality graphics, enhanced modelling
capabilities, and a new underlying architecture to facilitate
integration with third-party modelling and analysis tools.
($) - Similarly NCA equations for calculation of Cl, Volume etc. at
Steady State will only be valid when actually at Steady-State, since it
is only at this point you can make a reasonable assumption about the
amount of drug in the body after more than one dose has been given.
Senior Scientific Consultant
Pharsight- A Certara(tm) Company
Forthcoming meetings and training -http://www.pharsight.com/training;
WinNonlin 5.x IVIVC Toolkit - In Vivo-In Vitro Correlations: 4 Nov,
Cary, NC, USA.
Introduction to WinNonlin v6.0: 8-10 Dec, Paris, France.
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