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I am collecting bile samples over four to six intervals for up to 8 hr
after an intravenous administration of a compound. The amount of dosed
compound is measured in each sample and the sample volume is used to
calculate the total amount of the compound. I can plot the data as the
fraction of the administered dose (percent) relative to the mid-point
of the collection interval. These data are well fitted by a simple
hyperbolic function in WinNonlin and this gives me an asymptote
("Emax") value that I would like to interpret as the maximum amount of
compound that can be excreted. This would be most helpful for
situations where it is obvious that the curve is still rising at 8 hr.
My question to the group is, does anyone have a literature reference
for this approach? I have found a few articles that appeared to use
this approach but without any reference. Worse still, I would like to
apply this approach to cumulative urine data plotted in the same way.
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The following paper could answer some of your questions: Terziivanov,
D.et al. Pharmacokinetics and quantitative characterization of
Cefotiamexcretion ways after i.v. administartion in patinets after
cholecystectomy. Eur J ClinPharmacol., 1986, 30, 439-444.
Dimiter Terziivanov, MD,PhD,DSc,
Professor and Head, Clinic of Clinical Pharmacology and
Univ Hosp "St. Ivan Rilski", 15 Acad. Ivan Geshov st, 1431 Sofia,
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