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You can probably use hydroxypropyl Beta-cyclodextrins upto 1-2 % with
HBSS for low/sparingly soluble componds. Practicaly i have observed
no alteration in the monolayer integrity (alteration in TEER
measurement and Papp) of Caco2 monolayers.
You can go through this reference paper "EFFECT OF CYCLODEXTRINS ON
THE IN VITRO PERMEABILITY OF MODEL DRUGS THROUGH CACO-2 MONOLAYERS" by
D. Volpe, R. Hunt for further details.
Hope this information will help you in your mechanistic studies.
New Chemical Entity Research
Lupin Research Park
46A/47A, Village: Nande, Taluka: Mulshi
Pune-411 042, India
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