PharmPK Discussion - Accuracy and precision limit for drug estimation in TPN

• On 27 Aug 2010 at 08:30:46, ravi ravi ravi (ravi_s29.at.rediffmail.com) sent the message
  

  
  Dear Friends
  
  Present I am working on stability of Ceftazidime in Total Parenteral  Nutrition (TPN). The analytical HPLC method was developed, prior to  conducting the validation I would like to know the Accuracy and  precission limits.
  
  Can we consider the same bioanalytical (Accuracy and precission) limits  to the TPN Matrix ?
  
  For TPN 10% Accuracy and precission limits were reported by few authors.
  
  For example If we consider 15% of Accuracy and precission limits in  validation can we use the same limits in degradation study to conclude  the drug was stable in TPN.
  
  I will be very thankful for your feedbacks with some references
  
  Thank you
  
  Ravi
  
  

  Back to the Top

• On 27 Aug 2010 at 17:04:45, "Prof. Dr. Zafar Iqbal" (zafar_iqbal.aaa.upesh.edu.pk) sent the message
  

  
  Dear Ravi,
   With change in matrix type the parameters for the bioanalytical method  should be re-established.
  Dr zafar
  
  

  Back to the Top

• On 2 Sep 2010 at 04:22:12, Cool Minds (coolminds25.aaa.gmail.com) sent the message
  

  
  Dear Friends
  
  Present I am working on stability of Ceftazidime in Total Parenteral  Nutrition (TPN). I would like to know the Accuracy and precission  limits.
  In few papaers, 10% Accuracy and precission limits are reported by few  authors, for TPN. Can anybody tell me what limits i ll use?
   For example If i consider 15% of Accuracy and precission limits in  validation can i use the same limits in degradation study to conclude  the drug was stable/unstable in TPN.
  Or Can i consider the same bioanalytical (Accuracy and precission)  limits to the TPN Matrix ?
   I will be very thankful for your feedbacks with some references
  Thank you
   Shahid
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)