# PharmPK Discussion - Allometric exponents

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• On 31 Dec 2009 at 12:35:36, Md Tarique Imam (tarique.62.aaa.gmail.com) sent the message
`Dear Wang,I am a beginner in the pharmacokinetic field. I have read you  discussions on pharmacokinecs involving clearance, volume of  distribution and t1/2. I wanted to know how can be clearance or volume  of distribution determined by the formula V or  CL=A*(bodyweight)**B(exponent)From where the exponent (B) came and what is the rationale behind it.I am sure you'll help me for development of drugs using pharmacokinetics  and make me understand the concept behind it. I'll be waiting for you  positive response. Kind RegardsTarique, M. PharmJamia Hamdard, New DelhiIndia`
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• On 31 Dec 2009 at 13:45:44, "Conrad Housand" (chousand.-at-.acslx.com) sent the message
`The following message was posted to: PharmPKHave a look at this link for a discussion of the 3/4 power law forallometric scaling of things related to metabolic rate:http://en.wikipedia.org/wiki/Kleiber%27s_law`
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• On 1 Jan 2010 at 12:12:38, "Tushar Nahata" (tushar_nahata.aaa.rediffmail.com) sent the message
`Dear Tariq,I beleive that you should have to go through with books witten by  shargil and gibaldi. This will help you in all day to day PK releated  problems.With Regards,Dr. Tushar Nahata[See http://www.boomer.org/pkin/book.html- db]`
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• On 1 Jan 2010 at 15:10:59, Martin J Gnanamuthu (martinj.gnanamuthu.aaa.gmail.com) sent the message
`Hello Tarique,exponent (B) is the allometric exponent which explains the rate of  change of CL subjected to a change of body weight (mass).To explain a bit further, when this exponential form is transformed to a   linear function, this becomesas follows: Log(CL) = Log A + B Log (BW) and A , B can be estimated  from the intercept and slope of the linear regression. This slope (B)  explains the rate of change of CL with a change of body weight.Happy New yearRegards,Martin`
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