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I am pleased to announce the release of scaRabee, a new R package which constitutes a toolkit for modeling and simulation in the field of pharmacometrics. It was designed as a user-friendly interface to create and modify model scripts, define system observations and inputs, and run simulation or estimation analysis. scaRabee provides templates for the definition of pharmacokinetic-pharmacodynamic models with closed form solutions, ordinary or delay differential equations (which allows a easy implementation of life-span models). At the end of each analysis, scaRabee automatically generates diagnostic plots, report files with estimation statistics, and a log file with the history of the optimization process (for estimation runs). Optimization in scaRabee are performed using the simplex method of Nelder and Mead, implemented in the neldermead package.
scaRabee is available on CRAN
in version 1.0.
Any question, comment or feedback on this package is to be sent at: sb.pmlab.-a-.gmail.com.
Sebastien Bihorel, Pharm.D, Ph.D.
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