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The following message was posted to: PharmPK
Dear all,
I am looking for reviews about link between biomonitoring and PBTK.
Could someone be kind enough to help me?
Best regards
Jerome HENRI
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The following message was posted to: PharmPK
Jerome, here are some papers describing the use of PBTK for reverse dosimetry. I hope this helps.
Lyons MA, Yang RS, Mayeno AN, and Reisfeld B. (2008). Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data. Environ Health Perspect 116(8): 1040-1046.
Liao, KH, Tan, YM, and Clewell, HJ. (2007). Development of a screening approach to interpret human biomonitoring data on volatile organic compounds (VOCs): Reverse dosimetry on biomonitoring data for trichloroethylene. Risk Analysis 27: 12231236.
Tan, YM, Liao, KH, and Clewell, HJ. (2007). Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. Journal of Exposure Science and Environmental Epidemiology 71(7): 591603.
Clewell, HJ, Tan, YM, Campbell, JM, and Andersen, ME. (2008). Quantitative interpretation of human biomonitoring data. Toxicology and Applied Pharmacology 231L: 122-133.
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