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Hi All,
I would like to seek your opinion on what is the best or most intuitive self-learning kind of book to learn PK, PD and modeling concepts in the market. Many old-timers recommend Rowland and Tozer but I find this book to be pretty difficult to digest for an old horse with atrophied mathematical skills trying to learn new tricks. Any other suggestions. Thanks
Kind Regards,
M I Ahmad
[See http://www.boomer.org/pkin/book.html
for a list or http://www.boomer.org/c/p4/
and choose advanced for some online material - db]
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I highly recommend:
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications. John Gabrielsson and Dan Weiner. 4th Edition. ISBN: 91 9765 1001 (I think).
It provides in depth chapters on modeling with examples referenced throughout the text that are provided in more detail with coding in the back.
Happy reading,
Kristin Grimsrud
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Dear Mohmmad
one book is avialable which i have foung bit easy to understand is Biopharmaceutics by Brahmankar
Shital .
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I would recommend Pharmacokinetic-Pharmacodynamic Modeling and Simulation in addition to the Gabrielsson and Weiner book - especially if you want to delve in pharmacometric principles and concepts.
Rob
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The following message was posted to: PharmPK
I would recommend the book from Enne ETTE: Pharmacometrics: The Science of Quantitative Pharmacology
Ene I. Ette (Editor), Paul J. Williams (Editor) ISBN: 978-0-471-67783-3
Marc-Antoine
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Hi All,
After reading through a few hundred pages from Prof Rowland's book, I stumbled upon this book by Shagrel:
Applied Biopharmaceutics and Pharmacokinetics, third edition Stanford, Conn: Appleton and Lange; 1999.
I found the book to be quite decent and easy to understand. According to this article, it is the most popular book on PK it seems:
http://www.ajpe.org/view.asp?art=aj670247&pdf=yes
I wanted to order the book but was taken aback by some of the comments made here about the mathematical mistakes, etc :
http://www.amazon.com/Applied-Biopharmaceutics-Pharmacokinetics-Shargel-Bi opharmaceuticals/dp/0071375503/ref=dp_ob_title_bk
Then, I chanced upon this book by Winter with fantastic reviews but I have no access to it:
Basic Clinical Pharmacokinetics ,third edition. Vancouver, Wash: Applied Therapeutics, Inc; 1994.
Could anyone who has read the books make some comments about the good and bad about both books? I plan to order one of those and will probably get the 4th edition of Prof Rowland's book later.
Thanks
[Also, note I have a list of PK/PD books at http://www.boomer.org/pkin/book.html
nut no reviews ;-) - db]
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I like the one by Shargel and Lu. It really seems the most thorough.
All the best,
Roger Jelliffe
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The following message was posted to: PharmPK
Hi, Ahmad:
There's fifth eddition of Winter's Basic Clinical Pharmacokinetics, http://www.amazon.com/Basic-Clinical-Pharmacokinetics-Winter/dp/0781779030 /ref=sr_1_1?s=books&ie=UTF8&qid=1279922664&sr=1-1
I think this book is well written and very good to understand what clinical pharmacokinetics is in the practical therapuetic use of drugs. The basic principles are concise and easy to understand. The drug monographs and the exercise are good examples how to use the concept of clinical pharmacokinetics in practises.
If you are forcusing PK-PD modeling, that is out of the scope of this book.
Masaki Hiraoka
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Hi Imran Ahmad
Indeed, like other subjects, a single book for learning/teaching of pharmacokinetics could not be suggested. There are several books on the subject from very simple (Introduction of Pharmacokinetics by Bruce Clark, only 117 pages) to mathematics intensive texts. The choice of book would depend on purpose, teaching students at what level, requirement for industry or clinical settings. For example, Applied Biopharmaceutics and pharmacokinetics by Shargel has been my choice since my student life and now I am using it for teaching students in their 4 year of Pharm D. However, for dose calculation, we need book by another author, for instance, Basic Clinical Pharmacokinetics by Winter.
A list of pharmacokinetics books is not limited to the following ones (some are not updated).
1. Pharmacokinetics Made Easy by Birkett
2. Applied Biopharmaceutics and Pharmacokineitcs by Shargel
3. Clinical Pharmacokinetics-Concept and Applications by Rowland and Tozer
4. Clinical pharmacokinetics handbook by Bauer LA
6. Pharmacokinetics by Mehdi 7. Handbook of Basic Pharmacokinetics by Ritschel and Kearns
8. Applied Clinical Pharmacokinetics by Larry
9. Biopharmceutics and clinical pharmacokinetics by Milo Gibaldi
10. Basic Clinical Pharmacokinetics by Winter
11. Pharmacokinetic Principles of Dosing Adjustment by Roland
12. Introduction of Pharmacokinetics by Bruce Clark
13. Pharmacokinetics for the non-mathematical by Bourne
14. Biopharmaceutics by Sarfraz Niazi
Dr. Nadeem Irfan Bukhari
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The following message was posted to: PharmPK
Dear Imran:
I agree with you about Shargel and Lu as a good general PK book.
However, I don't understand why you would wish to look in a book to find out
the optimal drug dosage regimen for a patient. All you can get in a book is
a general dose for members of a general population.
I think you would do much better if you really tried to figure out
just how badly an individual patient needs a drug, and instead of using some
general "therapeutic range" where most, but certainly not all patients do
well, think instead of selecting a specific target goal such as a certain
serum concentration at a certain time, and then to use the appropriate
software to hit that goal as precisely as possible, with minimum weighted
squared error. This is now easily done for several drugs with appropriate
software. You will never find this in any book, as it is a specific
individualized regimen for that individual patient.
You might consider evaluating the MM-USCPACK software for this
purpose. It uses a combination of nonparametric population modeling and
"multiple model" dosage design, which specifically develops maximally
precise regimens to hit any stated target goal. Our web site www.lapk.org
has quite a good deal of general information on this subject, and if you put
in your contact information, we can give you permission to download and
evaluate this software.
Very best regards,
Roger Jelliffe
PS - I also like PK made easy, by Burkett. It is a super introduction.
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The following message was posted to: PharmPK
Dear Imran:
Somebody mentioned they liked Michael Winter for dosing, so I
thought I would put in my 2 cents worth. Shargel is good, but nobody has any
real approach to truly individualized dosing. You might go to our web page
http://www.lapk.org/pubsinfo/newadvances.php, and see there what we propose
for individualized dosing approaches. It is called PHARMACOMETRIC TOOLS TO
OPTIMIZE CONTROL OF DRUG PK/PD MODELS FOR BEST PATIENT CARE, and has the red letters NEW!
about it.
Very best regards,
Roger Jelliffe
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