PharmPK Discussion - Correct for residual concentration

• On 7 Sep 2010 at 10:16:25, Mastan SK (shkmastan.at.gmail.com) sent the message
  

  
  Hello,
   Please suggest me for the following question.
   How to correct for residual concentration of a drug if it has long half  life and registrable concentration was found in pre-dose sample in some  subjects?
   Thanks & regards,
  Mastan
  
  

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• On 7 Sep 2010 at 12:25:42, Toufigh Gordi (tgordi.at.yahoo.com) sent the message
  

  
  Hi Mastan,
  
  You don't provide any background info on what this study is for and what  the design was. If I guess correctly, you can detect drug concentration  prior to repeated dosing of the drug after wash-out periods.
  
  One way to go around it is to try a modeling approach. Once you have  build a compartmental PK model, you will be able to get the desired PK  parameters without a need to somehow "correct" for the pre-dose levels.
  Toufigh
  
  Toufigh Gordi, PhD
  Clinical Pharmacology, PK/PD analysis consultant
  www.tgordi.com
  E-mail: tg.-at-.tgordi.com
  
  

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• On 14 Sep 2010 at 12:18:18, "jayasagar.g" (jayasagar.g.-at-.advinus.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  I assume you are talking about predose concentrations in a crossover
  study.
  Calculate the AUC with the predose concentrations and subtract area
  contributed from the predose concentrations i.e. (AUCt-inf, where t is
  predose concentration).
  
  Regards,
  Jayasagar
  
  

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