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Dear All,
We have a compound where exposures are reduced 5 fold compared to day 1 on day 7 in a 7 day toxicity study!
We understand that this may be due to CYP induction. This compound is metabolically stable.
Are there any other reasons where we can observe decreased exposures relative to day 1 on day 7
Regards,
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Dear Sir,
For toxicity study you must have selected relatively higher dose than normal therapeutic dose.Constant high exposure of drug can also induce efflux transporter like P-gp which is a major hurdle for long term cancer therapy.
Hope this will help.
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