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Dear All,
Can any one let me know, what is the criteria to select a drug for IVIVC study (except BCS clascification).
thanks & Regards
R.Gopinath
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Dear Sir,
The other parameters need to be considered (other then BCS classification) while selecting a drug for IVIVC are
1. Metabolic Factors
2. Drug loss in the Gastrointestinal Tract
3. Sterochemistry of the drug
Kindly see the following literatures which will give better idea about the influence of parameters described above on Invitro-Invivo Correlation.
J. M. Vergnaud, I. D. Rosca. Assessing Bioavailability of Drug Delivery Systems - Mathematical Model. Taylor & Francis Group., 2005, 81-89.
T. J. Sullivan, R. G. Stoll, E. Sakmar, D. C. Blair, J. G. Wagner. J. Pharmakinet. Biopharm. 1974, 2: 29.
R. Dietrich, R. Brausse, G. Benedikt, V. W. Steinijans. Arzneim. Forsch. 1988, 38: 1229.
Thanks & Regards,
Dr.S.Gunasakaran,MBBS,MD,
Clinical Pharmacologist & Principal Investigator,
Azidus Research Laboratories,
Chennai
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