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may anyone suggest me a reference where elimination constant k(e) and b (as the exponential of the second phase: Bexp(-b*t)) in two-compartment model are definied in their physiological meaning and are related to drug excreted fraction?
Does k(e) represent elimnation rate before equilibrium between central and peripheral compartment and b after this equilibrium?
If there is not a linear relation between b and drug excreted fraction, comparing b and drug excreted fraction values in different patients, can I conclude that, even after long time, component Aexp(-a*t) is not negligible to consider b as representative of total body elimination phase?
Thank you very much in advance.
Sandro Ridone, PharmD, MSc
ENEA-Italian National Agency for New Technologies, Energy
and Sustainable Economic Development
Research Centre of Saluggia
Radiation Protection Institute
strada per Crescentino, 41
13040 Saluggia (VC)
[Are you confusing k(e) with beta? You might find the pages starting at:
useful. Note I use kel (or k10) instead of k(e). kel could be split into ke (excretion) and km (metabolism) as required - db]
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