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We are currently optimizing an NCE to obtain a longer half life. What are the general principles to be followed to enhance the half-life of NCEs?
I request medicinal chemistry experts to give some general ideas.
Dr Balakrishna Shankar.
Connexios Lifesciences Pvt Ltd
#49, Shilpa Vidya, 1st Main Road,
3rd Phase, JP Nagar,
Bangalore - 560078
India
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Try to get handle on clearance. Identify metabolic softs spots and work on that.
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