# PharmPK Discussion - Hepatic blood flow in each species

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• On 15 Mar 2010 at 09:30:24, wangjian (wj801126.at.hotmail.com) sent the message
`Hi, All:    I'm wondering if there are uniform values of hepatic blood flow for mouse, rat, dog, monkey and human, which are used to classify one compound as high, medium or low hepatic extraction. I have seen many different values used by different labs, different companies such as for rats, someone use 70 mL/min/kg, but someone use 55.2 mL/min/kg. And for mouse, someone use 90 mL/min/kg, but someone use 110 mL/min/kg. Which one is right? How can we use these hepatic blood flow to judge a compound's clearance? Thanks!Jian`
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• On 15 Mar 2010 at 15:29:14, "Stefano Porzio" (porzio.at.bioindustrypark.it) sent the message
`The following message was posted to: PharmPKDear Jian,to classify hepatic clearance, due to different blood flow in different species,  it's often suggested to use a "fraction of blood flow" (i.e. <20%, < 50%, <100%  or > 100%).Kind regardsStefano`
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• On 15 Mar 2010 at 14:43:08, "Simon Clark" (SJClark.-a-.pharm.co.uk) sent the message
`The following message was posted to: PharmPKDear Jian,Usually industry practices involve established values from literature and use these as the standard parameter which they compare Cl(p) against, as a relative degree of plasma clearance within species for the compound. For example stratified proportions of respective hepatic blood flow could be placed it to ranges as follows:Cl(p)        Q (HBF)LOW -      <1/3MEDIUM -    0.3-0.7HIGH-       >0.7VERY HIGH   Greater than Hepatic Blood FlowSorry my PBPK knowledge is basicIn general...Cl = QEWhere E is the extraction ratio of the compound by the liver or E= C blood in - C blood out                                                                   ------------------------                                                                         C blood inBut dont forget....Cl(plasma) = Cl (metabolic) + Cl (renal)And some well qualified (Pharm.Res 10 1093-1095) HBF values (ml/min/kg)Mouse (20-25g)       90Rat                  85Rabbit (2.5 - 3kg)   71Dog (10-12Kg)        31Monkey (4-5kg)       44Human (70kg)         21Really hope this helps, although I'm sure we'll be told otherwise : )Simon C`
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• On 18 Mar 2010 at 09:29:18, "Tausif Ahmed (Dr.)" (tausif.a.at.saiadvantium.com) sent the message
`The following message was posted to: PharmPKHi Jian,Thanks for sharing the values in detail. I just had doubt on the HBF value of rat. It is 55 ml/min/kg and not 85 ml/min/kg. Majority of the papers mention it as 55 ml/min/kg.Ref :  SJ Tschida et al. (1995)  Med. Clin. N. Amer. 79: 895-917          DD Breimer. (1987)  Pharm. Weekbl. Sci. 9: 79-84ThanksTausif Ahmed, Ph.D.Principal Scientist, DMPKSai Advantium Pharma Ltd., Pune`
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• On 18 Mar 2010 at 11:12:21, Clerk Maxwell (clerkmaxwell.aaa.hotmail.com) sent the message
`Neglect the clerkmaxwell name, as I am Harold Boxenbaum: While the reference below gives good values, I have conducted an extensive literature review, and I have come up with what I believe is the best value for HBF in humans, viz., 25 mL/min/kg.  Anyone can contact me for my calculation: Harold Boxenbaum, Ph.D.Pharmacokinetic ConsultantArishel Inc.14621 Settlers Landing WayNorth Potomac, MD 20878-4305`
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