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Thanks. I appreciate the information and note that the observation is
model based and not physiological. As I see it your quotation (copied
below) from the Benet paper is saying that elimination is reduced
rather than the volume of distribution being increased.
"The change in half-life is due to the redistribution of body fluids
with age causing more diazepam to distribute out of the fluids delivered
to the liver, the organ of elimination".
Which could be explained by a reduced rate of absorption from the gut.
I think the same effect would be caused by a reduced hepatic
extraction capacity although that seems less likely due to the small
amounts involved. On the other hand it's perhaps more probable as part
of a physiological ageing process than a reduced absorption since I
have not encountered that particular mechanism before.
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