PharmPK Discussion - Isobologram software

• On 2 Mar 2010 at 14:25:07, "Ming Chen" (ustc.pharm.aaa.gmail.com) sent the message
  

  
  Dear all:
   Recently my research focus on combination therapy. We employ factorial design in the experiment-two drugs were serially diluted and all possible pairs of diluted drug combinations were tested on each assay. Now I want to draw an isobologram according to the data. Then is the question: how to draw an isobologram?
   Thanks!
  
  [I found http://jpet.aspetjournals.org/content/298/3/865.full
  but no software - db]
  
  

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• On 2 Mar 2010 at 09:01:11, "Carol Collins" (carolc3.at.u.washington.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  Ming Chen:
  
  An excellent review of this topic was written by Ting-Chao Chou. http://pharmrev.aspetjournals.org/content/58/3/621.full.pdf+html
  He also developed a computer program called Combo Syn. I have never used it but it sells on their website. I do not know of any free software that performs this function.
  
  Carol Collins
  
  

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• On 3 Mar 2010 at 09:27:10, "Frederik B. Pruijn" (f.pruijn.at.auckland.ac.nz) sent the message
  

  
  Dear Dr. Chen,
  
  if you are "mathematically" inclined you could do it in Excel, for example. Other people have done this (search on "isobologram" AND "excel"). You could fork out money to buy CompuSyn or CalcuSyn. You could approach and collaborate with an expert (in return for a co-authorship?).
  
  Another recent article in Cancer Research:
  Drug combination studies and their synergy quantification using the Chou-Talalay method. Chou TC. Cancer Research. 70(2):440-6, 2010 Jan 15.
  HTH
  
  Frederik Pruijn
  
  

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