PharmPK Discussion - NONMEM Data Set

• On 21 Jul 2010 at 07:00:05, chandramouli Radhakrishnan (rcmoulirc.-a-.gmail.com) sent the message
  

  
  Hi
  Could anyone tell what should i do to make NONMEM work...
  My Dataset looks like this
  
  #ID  Time  Dose  DV     MDV
    01   00       20   05.2    0
    01   01       00   25.2    0
    01   02       00   55.2    0
    01   03       00   75.2    0
    01   24       00   05.2    0
    02   00       20   00.0    0
    02   01       00   25.2    0
    02   02       00   55.2    0
    02   03       00   75.2    0
    02   24       00   05.2    0
  
  This is how my data set looks and nonmem is coming out with an error  with SubID 01 as the initial conc = 5.2, when i comment out the first  patient i am not having issues in running my nonmem.
  
  Could someone please let me know how to work around this issue.  I tried  few options but nothing seems to work for me...Also could someone tell  me is there any place where i can look for solutions for the ERROR  messages that is coming out.
  
  -- Kind Regards
  
  Chandramouli Radhakrishnan
  
  

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• On 20 Jul 2010 at 21:18:10, "Rower, Joseph E" (Joseph.Rower.-at-.ucdenver.edu) sent the message
  

  
  It looks like your first line contains both a DOSE and a DV.  From my  understanding, NONMEM only permits one event to occur per line.  Try  eliminating the DV value from your first line, and adding it to a  subsequent line, as follows:
  
  #ID  Time  Dose  DV     MDV
    01   00       20   00.0    0
    01   00       00   05.2    0
    01   01       00   25.2    0
    01   02       00   55.2    0
  
  I hope that helps.
  
  Joseph Rower
  Graduate Student, Class of 2013
  Dept. of Pharmaceutical Sciences
  Univ of Colorado Health Sciences Center
  
  

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• On 21 Jul 2010 at 09:54:33, "Fakrudeen Ali Ahamed N.(ORLL-Biology)" (fakrudeen.at.orchidpharma.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Chandra Mouli,
  
  For Subject #1, at time "0" is it 5.2 or 0?
  
  Thanks
  FAA
  
  

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• On 21 Jul 2010 at 15:52:06, Chandramouli Radhakrishnan (rcmoulirc.at.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Fakrudeen,
  
  For subject #1, at time "0" is 5.2, as the subject is been taking the  drug for a while.
  
  Regards
  Mouli
  
  

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• On 21 Jul 2010 at 09:36:01, (soujanya.neni.-a-.sepracor.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Yes, I agree and try keeping MDV value as 1 at first line and DV as
  missing.
  Let me know how it works.
  Thanks,
  Soujanya.
  
  

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• On 22 Jul 2010 at 11:04:39, wangkun (fengdubianbian.at.hotmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  I think the MDV value of first line should be 1
  as follows
  
  #ID  Time  Dose  DV     MDV
  01   00       20   00.0    1    <--------------------here
  01   00       00   05.2    0
  01   01       00   25.2    0
  01   02       00   55.2    0
  
  Kun Wang  Ph.D
  Center for Drug Clinical Research
  Shanghai University of Chinese Medicine
  1200 Cailun Road, 201203 Shanghai, China
  
  

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• On 23 Jul 2010 at 22:15:08, "TKT (Thomas Klitgaard)" (tkt.at.novonordisk.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Kun Wan,
  
  Correct, and column should be called AMT instead of DOSE (or you should  have AMT=DOSE
  in $INPUT in your control stream). BR Thomas
  
  

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