Back to the Top
I would like to initiate a discussion about reporting pharmacokinetic parameters for metabolites using non-compartmental analysis. Typically for a metabolite, full AUC, partial AUC or metabolite to parent ratio is reported; however, some papers report metabolite half-life or MRT.
The question is, to define a metabolite kinetics, which parameters "should" or "should not be" reported.
Any suggestions are greatly appreciated.
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Pharmacokinetic parameters for a metabolite" as the subject
Support PharmPK by using the
Copyright 1995-2011 David W. A. Bourne (email@example.com)