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I have a (hopefully) simple question regarding PK analysis within Watson LIMS. I would like to analyze a single dose IV data set using noncompartmental modeling. The dose was administered as a bolus. The data set is as follows:
Time (hr) Conc (ng/mL)
0.083 2060
0.5 369
1 313
6 32.7
24 1.39
The AUC calculated by Watson LIMS is AUC 0.083-24 and is 1850 ng*hr/mL
When I analyze the data in WinNonlin (noncompartmental; model 201), the AUC calculated is 0-24 and is 2050 ng*hr/mL
It would appear that Watson LIMS is not calculating the AUC from 0-0.083 hr.
Does anybody know whether it is possible in WATSON LIMS to calculate an AUC0-24 hr from the above data set? Can the PK software inherent in Watson LIMS (not the Kinetica add on) back extrapolate this data set to calculate C0 and use that value for the calculation of AUC0-24?
On a related question, does anybody use the PK software that is built into Watson LIMS to analyze data from GLP Tox studies?
-- Regards,
Mark Milton
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The following message was posted to: PharmPK
Mark:
Embedded into Watson LIMS are the calculations that it is using or can
use. It is possible to select which formula you prefer to use for the
AUC calculation.
As for GLP Analysis, you can use it if you have validated the instance,
and locked in the formulas you want to use.
Mary
Mary M Sherman, Ph.D.
Aptuit Consulting, Inc.
91 Hartwell Avenue
Lexington, MA 02421
Email: Mary.Sherman.-at-.aptuit.com
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The following message was posted to: PharmPK
Mark,
For your data, the PKPlus module in GastroPlus gives:
NONCOMPARTMENTAL ANALYSIS OF DATA:
AUC = 1.941 ug-h/mL
AUMC = 3.780 ug-h^2/mL
MRT = 1.947 h
CL = 0.515 L/h
K(z) = 0.175 1/h
CL/kg= 7.358E-3 L/h/kg
Vss = 1.003 L
Vss/kg= 0.014 L/kg
C(0) bolus = 2.06 ug/mL
I assumed this was a bolus and used 70 kg body weight and 1 mg dose just to
get the values that depend on those parameters.
Walt Woltosz
Chairman & CEO
Simulations Plus, Inc. (NASDAQ: SLP)
42505 10th Street West
Lancaster, CA 93534-7059
U.S.A.
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