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We simulated human clearance from invitro data using montecarlo simulation in excel.(5000 observations)
The first question is, it is the same montecarlo simulation applied in other softwares to simulate the clearance value.
The second question is what is the % CV to be considered while simulating human clearance from in vitro data - 30% or more / less(more clearly what is the % CV to be considered from different parameters in the well stirred model like , clint, fublood, fuplasma, fumic).
With best regards,
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