Back to the Top
Dear All,
I will be so grateful if anybody gives me information on BCS class of =
Sirolimus.
=20
Parvin
=20
Parvin Zakeri-Milani, Pharm. D, Ph.D,
Associate Professor,
Faculty of Pharmacy,
Tabriz University of Medical Sciences
Tabriz, Iran
Email: pzakeri.-at-.tbzmed.ac.ir or parvinzm.-at-.yahoo.com=
Back to the Top
Hi Parvin,
According to a post in boomer.org it's Class 2 =
http://www.boomer.org/pkin/PK09/PK2009047.html
but I didn't see any reference related to that.=20
There's an article of Kasim was mentioned but your drug is not on the =
list.
[Nehal A. Kasim, Marc Whitehouse, Chandrasekharan Ramachandran,
Marival Bermejo, Hans Lennerna1s, Ajaz S. Hussain, Hans E. Junginger,
Salomon A. Stavchansky, Kamal K. Midha, Vinod P. Shah, and Gordon L.
Amidon 2003 Molecular Properties of WHO Essential Drugs and
Provisional Biopharmaceutical Classification, MOLECULAR PHARMACEUTICS,
VOL. 1, NO. 1, 85-96
Hope that helps somehow,
regards,
Zhengguo Xu
Bioanalisis y ADME Desarrollo
xzhengguo.-a-.esteve.es
Back to the Top
The following message was posted to: PharmPK
Dear Parvin
Sirolimus belongs to BCS Class-II (Low Solubility and High =
Permeability). Please refer the following article for BCS classification =
of various drugs.
Chi-Yuan Wu, Leslie Z. Benet. Predicting Drug Disposition via =
Application of BCS: Transport/Absorption/ Elimination Interplay and =
Development of a Biopharmaceutics Drug Disposition Classification =
System. Pharmaceutical Research. Volume 22, Number 1, 2005. pp. 11-23.
Best Regards
Sivacharan Kollipara
Research Scientist
Metabolism & Pharmacokinetics Department
Ranbaxy Laboratories Limited
Plot-GP-5, Sector-18
Udyog Vihar Industrial Area
Gurgaon - 122015
INDIA=
Back to the Top
The following message was posted to: PharmPK
Hi Parvin,
The following reference lists it as Class 2.
C.-Y. Wu and L. Z. Benet. Predicting drug disposition via application of =
bcs: transport/absorption/ elim- ination interplay and development of a=20=
biopharmaceutics drug disposition classification system. Pharm Res, =
22(1):11-23, Jan 2005.
Bart
Bart Laurijssens
BEL Pharm Consulting
Moulin d'Ozil, Chambonas 07140, France=
Back to the Top
The following message was posted to: PharmPK
According to Drug Bank
http://www.drugbank.ca/drugs/DB00877
Predicted water solubility: 1.73e-03 mg/mL
Predicted logP: 4.85
So, low solubility, high permeability, or Class 2
Also, see this thread from last fall
http://www.boomer.org/pkin/PK09/PK2009047.html
-Ian
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Sirolimus BCS" as the subject | Support PharmPK by using the |
Copyright 1995-2011 David W. A. Bourne (david@boomer.org)