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The following message was posted to: PharmPK
This is yet another interesting situation in that the dosing scheme is "twice daily" not "q 12hr". I have the second dose given 8 hours after the first then the next day's dose given 16 hours after the prior day last dose. Any special considerations here?
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In that case you will have to determine AUC (0-24) at steady state. Another words you will have to take blood sample through out the day. This situation is very common because it is more convenient to give the dose BID rather than q12hr. The latter dosing makes the PK evaluation simpler while the former dosing will require determination of plasma concentrations throughout the 24 hour period. I would love to hear if some one has more practical solution.
Regards, Aziz Karim
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The following message was posted to: PharmPK
Dear Aziz and timc79 :-),
You wrote:
> In that case you will have to determine AUC (0-24) at steady state. Another words you will have to take blood sample through out the day. This situation is very common because it is more convenient to give the dose BID rather than q12hr. The latter dosing makes the PK evaluation simpler while the former dosing will require determination of plasma concentrations throughout the 24 hour period. I would love to hear if some one has more practical solution.
>
More practical solution clinically would be to employ sparse sampling on Days 1 and 5, and possibly on days in between and after - with timepoints that make sense depending on the drug properties and on the clinical schedule of events, model all the data together, and based on the model predict the parameters of interest (AUCinf, AUCss,0-24, AUCss, 0-8, AUCss,8-24, etc).
Regards,
Katya
Ekaterina Gibiansky, QuantPharm LLC
www.quantpharm.com
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