PharmPK Discussion - Vehicle for nanosphere formulation

• On 27 Jul 2010 at 12:28:40, (suresh.b.at.anthembio.com) sent the message
  

  
  Hi,
  
  I have an issue with the nanospheres formulation (PLGA, PVA, Pluronics)  for intravenous administration in bolus and infusion in rodents and the  drug formulation is available in powder form.
  
  I have tried with phosphate buffer 0.1M and phosphate buffer saline  pH7.4 as the vehicle. Formulation is found to be a uniform suspension  but the particles is settling down and I am worried about the variation  in administration.
  
  Please suggest me a suitable vehicle and the permissible limits of  vehicles which can be used for our study.
  
  Thanks in advance?
  Awaiting your reply..
  Regards
  Suresh/Ravi
  
  

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• On 27 Jul 2010 at 10:26:07, "diaz, fanny" (fanny.diaz.-a-.mso.umt.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi,
  If the suspension leads to nanoparticles sedimentation, the system is
  not a colloidal suspension and in addition to pharmacokinetic variation
  you may experiment embolism associated with i.v. administration because
  of particles aggregation. I think the issue is more about the
  nanoparticles size (too big) than the vehicle which in you suspend the
  nanoparticles.
  Hope it will help,
  Fanny
  
  

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