PharmPK Discussion - AUC estimation using WinNonlin

• On 11 Feb 2011 at 21:22:06, Toufigh Gordi (tgordi.at.yahoo.com) sent the message
  

  
  Hi,
  
  We need to estimate various AUCs of a drug after an extravascular dose.  Does anybody know if an AUC0-tmax can be automatically estimated? Or  does one need to first find out the tmax for each individual and then  instruct the software to estimate each individual's AUC0-tmax by using  the individual tmax data one by one?
  
  Thanks!
  
  Toufigh
  
  Toufigh Gordi, PhD
  President, PK/PD and Clinical Pharmacology Services
  Rosa & Co. LLC (www.rosaandco.com)
  E-mail: tgordi.-a-.rosaandco.com
  
  

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• On 12 Feb 2011 at 09:35:39, Tim Cacek (timc79.-at-.centurytel.net) sent the message
  

  
  The following message was posted to: PharmPK
  
  I believe you need to determine tmax for each one and then use the partial
  area tab.
  
  

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• On 12 Feb 2011 at 16:53:30, Simon Davis (Simon.Davis.-at-.certara.com) sent the message
  

  
  Dear Dr Gordi,
                  I think this is a pretty simple step in the Phoenix  WinNonlin platform by using a "Join Worksheets" object after your NCA.   By making it an "Inner Join" you can use the "Tmax" from the "NCA Final  Parameters Pivotted" and merge it with the "Summary table" to return  only those records; the "AUC" column is a the cumulative AUC at that  point
   I've attached a screenshot here which you'll be able to see as I've  included your direct email but probably won't be visible to the rest of  the list so here's a link that should work;
    http://i768.photobucket.com/albums/xx321/Tamsins/phoenix_pk/Tmax_partial.j pg
     If this isn't clear, please can you post to the User Forum  (www.pharsight.com/extranet) where we can more easily exchange  photos/files to understand and resolve your problems better.  Finally  I'd like to remind all WNL5 and earlier users that that upgrading to  Phoenix WinNonlin 6.x is free for WinNonlin users with a valid  maintenance contract.  Phoenix 6.2 will be released shortly;  incorporating the IVIVC toolkit, NLME enhancements, remote processing  and also giving enhanced Windows 7 and MS Office 2010 support.
  
      Best regards,
                           Simon.
  --
  Simon.Davis.aaa.certara.com
  Senior Scientific Consultant
  Pharsight- A Certara(TM) Company
  
  [Thanks for the link Simon, it worked for me - db]
  
  

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