PharmPK Discussion - Blood sampling on rat feeding studies

• On 15 Sep 2011 at 10:06:42, Alexandra Gledhill (alex.at.robertcameron.com) sent the message
  

  
  Is there a standard sampling time set for taking bloood samples from
  rats on a long term toxicity study where the test compound is
  administered in the diet?  I'd like to take the minimum number of
  samples possible, to monitor exposure at various stages during the
  study.   Oral gavage studies show a prolonged absorption phase and half
  life>24 hours.  I seem to remember Dow agrosciences publishing a paper
  on this (for 2,4 D?) but can't find it.
  
  Cheers
  
  Alex
  
  

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• On 15 Sep 2011 at 22:13:58, "Saghir, Shakil (SA)" (SSaghir.at.dow.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Alex
  
  Here is the reference to the paper you need. We have made significant
  improvements since the publication of the paper, all of which will be
  published soon.
  
  Saghir SA, Mendrala AL, Bartels MJ, Day SJ, Hansen SC, Sushynski JM, Bus
  JS (2006). Strategies to assess systemic exposure of chemicals in
  subchronic/ chronic diet and drinking water studies. Toxicol Appl
  Pharmacol 211:245-260.
  
  --
  Shakil A. Saghir, M.S.P.H., Ph.D., DABT
  Senior Toxicology Specialist
  Toxicology & Environmental Research & Consulting
  The Dow Chemical Company
  Midland, Michigan 48674
  
  

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