PharmPK Discussion - CYP3A4 Inhibition by topical Erythromycin

• On 16 Aug 2011 at 17:34:46, Dorit Mimrod (Dorit.Mimrod.-at-.teva.co.il) sent the message
  

  
  Hi,
  
  Does anyone know if Erythromycin would still be considered a CYP3A4
  inhibitor if it is used topically ?
  
  Thanks a lot,
  Dorit
  
  

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• On 16 Aug 2011 at 09:38:39, Walt Woltosz (walt.-a-.simulations-plus.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dorit,
  
  An inhibitor remains an inhibitor regardless of route of administration.
  
  The question is, does it reach the tissues where 3A4 is expressed in
  sufficient quantity to have a significant effect on 3A4 metabolism. And that
  would depend on many factors. If the topical dose results in a plasma
  concentration of the inhibitor, then 3A4 inhibition in liver would occur -
  it's a question of degree.
  
  Best regards,
  
  Walt
  
  Walt Woltosz
  Chairman & CEO
  Simulations Plus, Inc. (NASDAQ: SLP)
  42505 10th Street West
  Lancaster, CA  93534-7059
  U.S.A.
  http://www.simulations-plus.com
  
  

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• On 16 Aug 2011 at 22:17:04, vijaya bhargava (vijayabhargava.k.-at-.gmail.com) sent the message
  

  
  I dont think so, if such is the case why ketoconazole will be used in
  antifungal treatment for dandruff (nizoral shampoo)
  
  

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