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Dear all pharmacokinetics Experts
I designed a pharmacokinetic experiment in rat model, using two formulations of one drug; (20 mg/kg-body weight): One was i.v. in HPCD, another one in CMC -sodium salt as an i.p. form. Indeed, my aim is to compare the pharmacokinetic profile of this drug in these two formulations and also looking for an evident of using HPCD as a vehicle of such drug, as this drug has poor water solubility. The results were as follows
Parameter a ZER/HPCD ZER/CMCb
complex (i.v.) suspension (i.p.)
T max (h) NA 1.98 +/- 0.06
C max ( ng/ml) NA 7960 +/- 48
AUC0-()() (ng.h/ml) 29861 +/- 51 21510 +/- 52
Vd (l/kg) 13.75 +/- 0.05 5.75 +/- 0.01
CL (l/h/kg) 0.97 +/- 0.002 0.68 +/- 0.01
So, my question is there any relationship between the parameters based in the above results, and also I need someone expert to explain in more details about the findings in terms of pharmacokinetics point of view.
Many thanks for any contribution
ELTAYEB E.M.EID RPhD Cancer Research lab./ Laboratory of Immunotherapeutic & Vaccines (LIVES) Institute of Bioscience
University Putra Malaysia
Selangor 43400, Serdang, Malaysia
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