PharmPK Discussion - Early concentrations after IV

• On 15 Dec 2011 at 23:37:44, MJ (zmj04131039.-a-.163.com) sent the message
  

  
  Dear all,
  A test article was given to animals by IV bolus several day before. But
  the BA data suggest that the plasma concentration at 5 min < 15 min.
  I really feel confused on this. Can anyone give me some explanation for
  me? I'll appreciate it if you can give me some documents.
  Thanks in advance,
  MJ
  
  PS: There were many clinical observations within the first 15min, such
  as tremors, decreased activities and lethargy. I don't know whether
  these symptoms will affect PK behavior or not.
  
  

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• On 15 Dec 2011 at 14:58:03, "Shoaf, Susan" (Susan.Shoaf.aaa.otsuka-us.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hello,
  
  What is the IV formulation and how insoluble is your drug?
  
  I had a formulation of trimethoprim where the drug did not remain in
  solution once injected into the jugular vein of Holstein calves.  The
  drug then solubilized and gave a peak 15 to 30 min later.
  
  Susan
  
  

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• On 16 Dec 2011 at 19:08:52, Garima Balwani (garimabalwani.-at-.gmail.com) sent the message
  

  
  It can happen probably because of the lag time in transport of drug in
  the blood stream.. i hope attached article can help you.. [not attached
  - ref below - db]
  --
  Garima Balwani
  Research Scholar
  Department of Pharmacy
  BITS-Pilani, Pilani campus
  
  Weiss, M. (1983). Modelling of initial distribution of drugs following
  intravenous bolus injection. European journal of clinical pharmacology,
  24(1), 121-126. Springer.
  
  

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• On 16 Dec 2011 at 22:22:29, vijaya bhargava (vijayabhargava.k.-a-.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  But, will there be any lag time in IV route because the Lag time in
  pharmacokinetics corresponds to the finite time taken for a drug to
  appear in systemic circulation following extravascular administration
  i.e not iv . Lag time is a reflection of the processes associated with
  the absorption phase such as drug dissolution and/or release from the
  delivery system and drug migration to the absorbing surface.
  
  So I doubt there should be some formulation issues only.
  
  Was the study repeated under identical conditions of the previous one?
  if so, how the data looks like. There could also be a chance, if the
  total drug injected did not enter the systemic circulation, i mean
  some amount might be left outside when drawing the needle back and act
  as a depot preparation..any further ideas.
  
  vijayabhargava
  
  

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• On 16 Dec 2011 at 15:35:53, Ayyappa Chaturvedula (ayyappach.-at-.yahoo.com) sent the message
  

  
  Is it possible for the drug to precipitate in lungs? Does it have poor solubility?
  
  Regards,Ayyappa Chaturvedula
  
  

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