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The following message was posted to: PharmPK
Can the users here recommend any commercial programs (US or otherwise) that are able to incorporate multiple patient parameters into the empiric or sparse sampling-guided individualization of approved drugs? I am presuming these programs would be incorporating Bayesian algorithms, but I am looking for commercial programs that have a more clinician-friendly front-end than programs such as NONMEM with MAXEVAL=0.
Many thanks!
Paul
-- Paul R. Hutson, Pharm.D.
Associate Professor
UW School of Pharmacy
777 Highland Avenue
Madison WI 53705-2222
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[I seem to have received the first email on this topic at all my accounts!!! Maybe this is the second one for you from PharmPK in some time. I'm not sure why the ****SPAM**** in the subject but it could be useful to add pharmpk.-at-.boomer.org to you favorites, contact list or whitelist, thanks - db]
The following message was posted to: PharmPK
Paul,
Our Laboratory of Applied Pharmacokinetics at the University of Southern California has user-friendlier Windows software designed to optimize doses in patients using Multiple-Model Bayesian Adaptive Control. We are not a commercial outfit, however several hundred users have downloaded the software. I am an infectious diseases physician and clinical pharmacologist, and I have used it many times to rapidly achieve desired drug concentrations with maximum precision in my patients. You can find a representative paper of our lab and the software at J Clin Pharmacol. 2008 Sep;48(9):1081-91. A more recent paper from another group is Ann Pharmacother. 2011 Jun;45(6):757-63, although these authors did not use the software to dose the patients, but simply to fit a model of vancomycin to past observations. We have added some new function to the software that can improve even upon the -3.1% prediction bias that they observed.
Please feel free to contact me if you'd like to learn more. --
Michael Neely, MD
Laboratory of Applied Pharmacokinetics
2250 Alcazar St. CSC 134B
Los Angeles, CA 90033
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Dear Michael
Could you please send me the link to download this software.
Kind Regards
Chandramouli
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The following message was posted to: PharmPK
This might be MM-USCPACK version 15.2 from =
http://www.lapk.org/software.php
via the PharmPK list of PK software at http://www.pharmpk.com/soft.html
> Could you please send me the link to download this software.
>=20
> Kind Regards
> Chandramouli
[PS Roger can you confirm this link as the best source for the software? =
Thanks - db]
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The following message was posted to: PharmPK
Dear Chandramouli:
Thanks for your email. Go to our web site www.lapk.org and click on
software, then on 'download'. It goes to the restricted page that says =
"please
sign in". Click that. Then it asks you for your email and password. But =
look
down at the bottom. In little blue letters is says "register". That is =
where
you put in your contact information and click "submit query". That is =
when
Michael and I get an email, and then give you access, with a confirming
email back to you. When putting in your contact info, click on whether =
you
are An academic or a commercial user. You are probably academic. When =
you
wish to buy, that is what determines the license fee.
Very best regards,
Roger Jelliffe and Michael Neely=
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The following message was posted to: PharmPK
Dear Paul,
As one of its developers and scientic advisors, I suggest to consider =
the program MwPharm. Although the current full version is still a =
DOS-version, a demo version of the Windows version is available from =
http://www.mediware.nl/
This version will be extended to the full functionality of the DOS =
version in the next future.
MwPharm is a general clinical pharmacokinetic program designed for daily =
clinical practice, including dosage regimen calculation, parameter =
estimation based on measured plasma levels after any medication history, =
Bayesian feedback, population pharmacokinetic analysis, and many more. =
The program has a database with pharmacokinetic parameters of about 180 =
drugs, but data of new drugs can be entered and stored unlimited. Linear =
and Michaelis-Menten elimination kinetics and 2- and 3-compartmental =
models, in any combination, are included. The program calculates dosing =
regimens based on the therapeutic window, pharmacokinetic parameters, =
and individual patient characteristics. The medication history can take =
into account any dosing and sampling schedule, changing creatinine =
level, changing body weight, and extracorporeal clearance. In addition, =
effect - time profiles can be calculated according to the sigmoid Emax =
model or the 'growth-kill' model for antibiotics.
The program includes a module for population analysis based on an =
Iterative Two-Stage Bayesian procedure, which allows an easy, fast and =
reliable generation of population parameters from the patient data =
stored in the database. It also contains a module for the assessment of =
optimal limited sampling times to estimate AUC from a single or a few =
sampling points.
MwPharm is widely used by hospital pharmacists in the Netherlands and in =
many other countries.
Further information can be obtained via info.at.mediware.nl.
best regards,
Hans Proost
Johannes H. Proost
Dept. of Pharmacokinetics, Toxicology and Targeting
University Centre for Pharmacy
Antonius Deusinglaan 1
9713 AV Groningen, The Netherlands=
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