PharmPK Discussion - Felodipine metabolism

• On 25 Mar 2011 at 14:48:59, Rachel Mandell (rmandell.-a-.rigel.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  I am researching Felodipine metabolism in human and rat and I am having  trouble with a
  couple of questions.
  
  1) What is the specific 3A isozyme in rat that metabolizes Felodipine?
  
  2) Are there other pathways of metabolism in rat or human? If so, what  isozymes are
  involved?
  
  So far I can establish that 3A4 is the major pathway in man and that  Felodipine is not a
  substrate for human or rat P-gp.
  
  Thanks so much for your help,
  Rachel
  
  

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