PharmPK Discussion - Fish tank model

• On 6 Feb 2011 at 15:44:08, "DAN BROWN" (DAN_BROWN.aaa.pba.edu) sent the message
  

  
  Please forward the following to the PK/PD  listserve:
  
  I teach Clinical PK in a school of pharmacy and I hope that an old-timer  out there might be able to help me locate a reference from the 70's.  An  old PK textbook from that time period included a great metaphor for  helping students understand first-order elimination.  It was the  elimination of fish from a fish tank using a net.  I photocopied an  illustration from the book and saved it, but I can neither locate the  book nor recall the title or author.  The illustration of the fish tank  model from that book is attached.
  
  If any of you are familiar with the book that contains the illustration,  or if you know of other PK resources that describe the "fish tank model'  of first-order elimination, please reply.
  
  Thanks.
  Dan Brown
  Professor
  Gregory School of Pharmacy
  Palm Beach Atlantic University
  daniel_brown.-a-.pba.edu
  
  

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• On 7 Feb 2011 at 02:41:00, Henri Merdjan (Henri.Merdjan.aaa.certara.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dan,
  
  I have been teaching PK on an occasional basis, and I have consistently  used the analogy of eliminating flies (not fish) from a closed tank,  using a propeller rather than a net. The metaphor is not mine. I took it  from the "Handbook of basic pharmacokinetics, 1st edition 1976 by  Wolfgang Ritschel.
  Hope it helps,
  
  Henri
  
  Henri Merdjan
  Senior Director, Pharsight Consulting Services Europe
  www.pharsight.com
  
  

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• On 7 Feb 2011 at 11:00:32, Joseph Chamberlain (spiresgate.at.tiscali.co.uk) sent the message
  

  
  The following message was posted to: PharmPK
  
  Sounds like Larry Gifford of Manchester.
  
  Or possibly Geoff Tucker of Sheffield.
  
  Joe Chamberlain
  
  

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