PharmPK Discussion - Formulation for IV and SC route

• On 25 Mar 2011 at 14:00:02, nagsen gautam (nagsengautam.at.rediffmail.com) sent the message
  

  
  Hi all,
  
  I have a novel compound for Pre-clinical screening by I.V. and  sub-cutaneous route. The
  compound is non-polar, it is not soluble in  Ethanol, soluble in DMSO. Can anyone suggest
  for suitable co-solvents  and their limits for dosing in animals by these route.
  
  Nagsen Gautam
  
  

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• On 25 Mar 2011 at 15:25:10, "Beaupre,AJ" (AJ.Beaupre.-a-.colostate.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hello,
  
  I found this paper to be exceptionally helpful when I was developing
  formulations for our lab.
  
  Int J Pharm. 2007 Aug 16;341(1-2):1-19. Epub 2007 May 26.
  Developing early formulations: practice and perspective.  Li P , Zhao L
  
  AJ Beaupre
  
  

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• On 26 Mar 2011 at 11:05:43, "L. Chakradhar" (chakradhar_shetty.-at-.yahoo.co.in) sent the message
  

  
  Hi gautam,
  
  There are some excellent review articles which talk about this. Usually  for preclinical
  studies, use either cosolvency or pH adjustment or use  of buffers for making solution.
  The order of cosolvents for making  solution also makes the difference. I suggest, use
  PEG400 or PEG200  (20%). I usually found N-methylpyrrolidene (around 10%) to be a good
  cosolvent for highly lipophilic compounds. Try changing the pH and if  you still have
  problems, use buffers instead of saline.
  
  Regards
  
  

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• On 27 Mar 2011 at 13:38:41, jaydeep sinha (jsinha83.aaa.gmail.com) sent the message
  

  
  Hi..
  total cosolvent content should be <15% in SC formulation. SC route has  the highest constraints in using cosolvents because of the very slow  rate of diffusion from the administration site and rich nerve supply.  here is another article which very useful..
  
  Solubilizing Excipients in Oral and Injectable Formulations; Robert G.  Strickley; Pharmaceutical Research, Vol. 21, No. 2, February 2004
  
  Jay
  
  

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• On 28 Mar 2011 at 07:55:41, "Tahraoui, Ahmed" (Ahmed.Tahraoui.aaa.crl.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi,
  
  The use of 10% NMP is not documented, can you please give us the
  reference in which you found the information!
  
  

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